Activation of autoreactive T cells by peptides from human pathogens

Adult Thymus: A Forgotten Jail for Autoreactive T Cells

Autoreactive T and B Cells from Bullous

Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation.

T cells play a significant role in the pathogenesis of systemic autoimmune diseases, including systemic lupus erythematosus; however, there is relatively little information on the nature and specificity of autoreactive T cells. Identifying such cells has been technically difficult because they are likely to be rare and low affinity. Here, we report a method for identifying autoreactive T cell c...

Regulatory role of TLR ligands on the activation of autoreactive T cells by retinal astrocytes.

PURPOSE To determine whether Toll-like receptor (TLR) ligands regulate the activation of retinal astrocytes (RACs) and the possible role of RACs in the polarization of interphotoreceptor retinoid-binding protein (IRBP)-specific T cells. METHODS TLR expression on RACs isolated from C57BL/6 mice was examined using real-time PCR and flow cytometry. The ability of RACs before or after treatment w...

Autoreactive T Cells B1 Cells Promote Pancreas Infiltration By